Exponent states that chromium polynicotinate is a mixture of chromium dinicotinate and chromium trinicotinate, with the latter being the predominant form. Exponent describes chromium polynicotinate as an oxygen-coordinated, niacin-bound trivalent chromium complex. ![]() Based on this review and the totality of scientific evidence, Exponent’s GRAS panel concluded that chromium polynicotinate, produced in accordance with current good manufacturing practice (cGMP) and meeting described specifications, is GRAS under the intended conditions of use.Įxponent provides information on the identity and composition of chromium polynicotinate. Exponent’s GRAS panel reviewed the identity and composition, method of manufacture, specifications, and intended use and dietary exposure to chromium polynicotinate, as well as publicly available studies supporting the safety of chromium polynicotinate. Exponent considers the members of its GRAS panel to be qualified by scientific training and experience to evaluate the safety of substances added to food. (Exponent) that chromium polynicotinate is GRAS, through scientific procedures, for use as an ingredient in enhanced water beverages at a maximum use level of 575 micrograms per liter (µg/l).Īs part of its notice, Exponent includes a statement from a panel of individuals (Exponent’s GRAS panel) that evaluated the data and information that are the basis for Exponent’s GRAS determination. The notice informs FDA of the view of Exponent, Inc. The subject of the notice is chromium polynicotinate. FDA received the notice on December 9, 2015, filed it on December 15, 2015, and designated it as GRAS Notice No. The Food and Drug Administration (FDA) is responding to the notice, dated December 8, 2015, that you submitted in accordance with the agency’s proposed regulation, proposed 21 CFR 170.36 (62 FR 18938 ApSubstances Generally Recognized as Safe (GRAS) the GRAS proposal). See also Generally Recognized as Safe (GRAS). Return to inventory listing: GRAS Notice Inventory
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